Assay Detail
Binding
CHEMBL898688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 15-hLO1
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL2903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.22 | 5.51 |
| Ki | 2 | 5.10 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323197 | MANGOSTIN | — | 1 | 5.51 |
| CHEMBL397803 | MISCHELLAMINE B | — | 1 | 5.12 |
| CHEMBL391079 | DYSIDENIN | — | 1 | 5.10 |
| CHEMBL238624 | — | — | 1 | 5.03 |
| CHEMBL392270 | NEODYSIDENIN | — | 2 | - |
| CHEMBL222808 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323197 | MANGOSTIN | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL397803 | MISCHELLAMINE B | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL391079 | DYSIDENIN | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL238624 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL392270 | NEODYSIDENIN | IC50 | > | 500000.0 | nM | - |
| CHEMBL222808 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL392270 | NEODYSIDENIN | Ki | > | 500000.0 | nM | - |