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Compound Detail

CHEMBL397803

MISCHELLAMINE B
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COc1cc(C)cc2c(-c3c(O)cc(O)c4c3C[C@@H](C)N[C@@H]4C)cc(-c3ccc4c(-c5c(O)cc(O)c6c5C[C@@H](C)N[C@@H]6C)c(C)cc(OC)c4c3O)c(O)c12

Basic Information

ChEMBL ID CHEMBL397803
Name MISCHELLAMINE B
Phase Preclinical
Structure Type MOL
InChI Key BWZFGUKJQQFBKY-MOUTVQLLSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

756.9
MW (Da)
9.05
ALogP
10
HBA
8
HBD
163.9
PSA (Ų)
0.09
QED
3
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C46H48N2O8
MW 756.90
Aromatic Rings 6
Heavy Atoms 56
NP-Likeness 1.23

Activity Summary

IC50 2 meas. best 5.31

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Polyunsaturated fatty acid lipoxygenase ALOX12
CHEMBL3687
IC50 5.31 5.31 4900.0 1
Polyunsaturated fatty acid lipoxygenase ALOX15
CHEMBL2903
IC50 5.12 5.12 7600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17826100 10.1016/j.bmc.2007.08.015 Polyunsaturated fatty acid lipoxygenase ALOX15 4
17826100 10.1016/j.bmc.2007.08.015 Polyunsaturated fatty acid lipoxygenase ALOX12 3
17826100 10.1016/j.bmc.2007.08.015 Unchecked 1

Data from ChEMBL 36 via Core Engine