Assay Detail
Binding
CHEMBL898995
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Rational design, synthesis and evaluation of (6aR( *),11bS( *))-1-(4-fluorophenyl)-4-{7-[4-(4-fluorophenyl)-4-oxobutyl]1,2,3,4,6,6a,7,11b,12,12a(RS)-decahydropyrazino[2',1':6,1]pyrido[3,4-b]indol-2-yl}-butan-1-one as a potential neuroleptic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.60 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393466 | — | — | 1 | 9.19 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.24 |
| CHEMBL136711 | BIRIPERONE | 2.0 | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393466 | — | Ki | = | 0.6427 | nM | 9.19 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 58.08 | nM | 7.24 |
| CHEMBL136711 | BIRIPERONE | Ki | = | 424.62 | nM | 6.37 |