Compound Detail
CHEMBL136711
BIRIPERONE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL136711 |
| Name | BIRIPERONE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | YCNCIZWAGQTWBI-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
3
Known Names
Molecular Properties
391.5
MW (Da)
4.01
ALogP
3
HBA
1
HBD
39.3
PSA (Ų)
0.67
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
Ki 4 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(3) dopamine receptor CHEMBL234 | Ki | 7.96 | 7.96 | 11.0 | 1 |
| D(2) dopamine receptor CHEMBL339 | Ki | 7.88 | 7.88 | 13.2 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL322 | Ki | 7.62 | 7.62 | 24.0 | 1 |
| D(1A) dopamine receptor CHEMBL265 | Ki | 6.37 | 6.37 | 424.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(3) dopamine receptor | Ki | = | 11.0 | nM | 7.96 | Ability to compete with [3H]YM-09151-2 binding to the human dopamine receptor D3... | 14521403 |
| D(2) dopamine receptor | Ki | = | 13.18 | nM | 7.88 | Displacement of [3H]spiperone from dopamine D2 receptor in rat brain | 17869521 |
| 5-hydroxytryptamine receptor 2A | Ki | = | 24.04 | nM | 7.62 | Displacement of [3H]ketanserin from 5HT2A receptor in rat brain | 17869521 |
| D(1A) dopamine receptor | Ki | = | 424.62 | nM | 6.37 | Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain | 17869521 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17869521 | 10.1016/j.bmc.2007.07.018 | Rattus norvegicus | 5 |
| 17869521 | 10.1016/j.bmc.2007.07.018 | Mus musculus | 3 |
| 14521403 | 10.1021/jm030085p | D(3) dopamine receptor | 1 |
| 17869521 | 10.1016/j.bmc.2007.07.018 | D(1A) dopamine receptor | 1 |
| 17869521 | 10.1016/j.bmc.2007.07.018 | D(2) dopamine receptor | 1 |
| 17869521 | 10.1016/j.bmc.2007.07.018 | 5-hydroxytryptamine receptor 2A | 1 |
| 17869521 | 10.1016/j.bmc.2007.07.018 | Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a) | 1 |
Data from ChEMBL 36 via Core Engine