Assay Detail
Binding
CHEMBL899146
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Displacement of [3H]QNB from human muscarinic M5 receptor expressed in CHO cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Muscarinic acetylcholine receptor M5 (CHEMBL2035) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 5.72 | 7.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 7.45 |
| CHEMBL275104 | — | — | 1 | 6.29 |
| CHEMBL398043 | — | — | 1 | 6.26 |
| CHEMBL239038 | — | — | 1 | 5.74 |
| CHEMBL239436 | — | — | 1 | 5.39 |
| CHEMBL239866 | — | — | 1 | 5.29 |
| CHEMBL396845 | — | — | 1 | 5.25 |
| CHEMBL239655 | — | — | 1 | 5.20 |
| CHEMBL428916 | — | — | 1 | 5.16 |
| CHEMBL238825 | — | — | 1 | 5.12 |
| CHEMBL240763 | — | — | 1 | - |
| CHEMBL239017 | — | — | 1 | - |
| CHEMBL239657 | — | — | 1 | - |
| CHEMBL239652 | — | — | 1 | - |
| CHEMBL394329 | — | — | 1 | - |
| CHEMBL239438 | — | — | 1 | - |
| CHEMBL239865 | — | — | 1 | - |
| CHEMBL239644 | — | — | 1 | - |
| CHEMBL397538 | — | — | 1 | - |
| CHEMBL395114 | — | — | 1 | - |
| CHEMBL239426 | — | — | 1 | - |
| CHEMBL240764 | — | — | 1 | - |
| CHEMBL397083 | — | — | 1 | - |
| CHEMBL238827 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9967 | PIRENZEPINE | Ki | = | 35.48 | nM | 7.45 |
| CHEMBL275104 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL398043 | — | Ki | = | 544.0 | nM | 6.26 |
| CHEMBL239038 | — | Ki | = | 1836.0 | nM | 5.74 |
| CHEMBL239436 | — | Ki | = | 4116.0 | nM | 5.39 |
| CHEMBL239866 | — | Ki | = | 5139.0 | nM | 5.29 |
| CHEMBL396845 | — | Ki | = | 5664.0 | nM | 5.25 |
| CHEMBL239655 | — | Ki | = | 6310.0 | nM | 5.20 |
| CHEMBL428916 | — | Ki | = | 6885.0 | nM | 5.16 |
| CHEMBL238825 | — | Ki | = | 7514.0 | nM | 5.12 |
| CHEMBL240763 | — | Ki | - | — | - | |
| CHEMBL239017 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL239657 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL239652 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL394329 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL239438 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL239865 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL239644 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL397538 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL395114 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL239426 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL240764 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL397083 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL238827 | — | Ki | > | 10000.0 | nM | - |