Assay Detail
Functional
CHEMBL899159
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Cytotoxicity against human multidrug resistant Lucena1 cells assessed as cell viability after 48 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Natural triterpenoids from Cecropia lyratiloba are cytotoxic to both sensitive and multidrug resistant leukemia cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.18 | 4.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439053 | — | — | 1 | 4.38 |
| CHEMBL239296 | — | — | 1 | 4.14 |
| CHEMBL239077 | TOMENTIC ACID | — | 1 | 4.10 |
| CHEMBL239075 | EUSCAPHIC ACID | — | 1 | 4.08 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439053 | — | IC50 | = | 41380.0 | nM | 4.38 |
| CHEMBL239296 | — | IC50 | = | 72870.0 | nM | 4.14 |
| CHEMBL239077 | TOMENTIC ACID | IC50 | = | 80250.0 | nM | 4.10 |
| CHEMBL239075 | EUSCAPHIC ACID | IC50 | = | 83790.0 | nM | 4.08 |
| CHEMBL90555 | VINCRISTINE | IC50 | > | 100.0 | nM | - |