Assay Detail
ADMET
CHEMBL899348
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Inhibition of human CYP3A4
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.94 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1471 | APREPITANT | 4.0 | 1 | 7.34 |
| CHEMBL235882 | — | — | 1 | 4.96 |
| CHEMBL391964 | — | — | 1 | 4.96 |
| CHEMBL391963 | — | — | 1 | 4.75 |
| CHEMBL392463 | — | — | 1 | 4.64 |
| CHEMBL392464 | — | — | 1 | 4.55 |
| CHEMBL391615 | — | — | 1 | 4.31 |
| CHEMBL392465 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1471 | APREPITANT | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL235882 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL391964 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL391963 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL392463 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL392464 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL391615 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL392465 | — | IC50 | = | 100000.0 | nM | 4.00 |