Assay Detail
ADMET
CHEMBL899349
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Inhibition of human CYP2D6
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.25 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391963 | — | — | 1 | 4.62 |
| CHEMBL391615 | — | — | 1 | 4.24 |
| CHEMBL392465 | — | — | 1 | 4.20 |
| CHEMBL235882 | — | — | 1 | 4.14 |
| CHEMBL391964 | — | — | 1 | 4.04 |
| CHEMBL392464 | — | — | 1 | - |
| CHEMBL392463 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391963 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL391615 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL392465 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL235882 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL391964 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL392464 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL392463 | — | IC50 | > | 100000.0 | nM | - |