Assay Detail
Binding
CHEMBL899495
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Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.67 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL238365 | — | — | 1 | 8.01 |
| CHEMBL396656 | — | — | 1 | 7.96 |
| CHEMBL427678 | — | — | 1 | 7.83 |
| CHEMBL238366 | — | — | 1 | 7.43 |
| CHEMBL391548 | — | — | 1 | 7.40 |
| CHEMBL235159 | — | — | 1 | 7.25 |
| CHEMBL235378 | — | — | 1 | 7.21 |
| CHEMBL235379 | — | — | 1 | 6.84 |
| CHEMBL392827 | — | — | 1 | 6.70 |
| CHEMBL391549 | — | — | 1 | 6.64 |
| CHEMBL443579 | — | — | 1 | 6.02 |
| CHEMBL394392 | — | — | 1 | 6.00 |
| CHEMBL235784 | — | — | 1 | 5.88 |
| CHEMBL238338 | — | — | 1 | 5.81 |
| CHEMBL235601 | — | — | 1 | 5.72 |
| CHEMBL266491 | — | — | 1 | 5.65 |
| CHEMBL238340 | — | — | 1 | 5.09 |
| CHEMBL445409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL238365 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL396656 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL427678 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL238366 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL391548 | — | IC50 | = | 39.9 | nM | 7.40 |
| CHEMBL235159 | — | IC50 | = | 56.7 | nM | 7.25 |
| CHEMBL235378 | — | IC50 | = | 61.2 | nM | 7.21 |
| CHEMBL235379 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL392827 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL391549 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL443579 | — | IC50 | = | 955.0 | nM | 6.02 |
| CHEMBL394392 | — | IC50 | = | 989.0 | nM | 6.00 |
| CHEMBL235784 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL238338 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL235601 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL266491 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL238340 | — | IC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL445409 | — | IC50 | > | 10000.0 | nM | - |