Compound Detail
CHEMBL235378
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Basic Information
| ChEMBL ID | CHEMBL235378 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JDHUDWCHCQEQBK-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
263.2
MW (Da)
3.95
ALogP
2
HBA
1
HBD
44.0
PSA (Ų)
0.85
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Androgen receptor CHEMBL1871 | IC50 | 7.92 | 7.565 | 11.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Androgen receptor | IC50 | = | 11.9 | nM | 7.92 | Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assay | 17764935 |
| Androgen receptor | IC50 | = | 61.2 | nM | 7.21 | Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cells | 17764935 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17764935 | 10.1016/j.bmcl.2007.08.034 | Androgen receptor | 2 |
| 17764935 | 10.1016/j.bmcl.2007.08.034 | Progesterone receptor | 1 |
Data from ChEMBL 36 via Core Engine