Assay Detail
Functional
CHEMBL899496
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.82 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391548 | — | — | 1 | 10.70 |
| CHEMBL235159 | — | — | 1 | 9.10 |
| CHEMBL235378 | — | — | 1 | 7.92 |
| CHEMBL238366 | — | — | 1 | 7.70 |
| CHEMBL443579 | — | — | 1 | 6.85 |
| CHEMBL427678 | — | — | 1 | 6.40 |
| CHEMBL392827 | — | — | 1 | 6.07 |
| CHEMBL394392 | — | — | 1 | - |
| CHEMBL235784 | — | — | 1 | - |
| CHEMBL445409 | — | — | 1 | - |
| CHEMBL266491 | — | — | 1 | - |
| CHEMBL238338 | — | — | 1 | - |
| CHEMBL238340 | — | — | 1 | - |
| CHEMBL235601 | — | — | 1 | - |
| CHEMBL238365 | — | — | 1 | - |
| CHEMBL391549 | — | — | 1 | - |
| CHEMBL396656 | — | — | 1 | - |
| CHEMBL235379 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391548 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL235159 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL235378 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL238366 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL443579 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL427678 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL392827 | — | IC50 | = | 843.0 | nM | 6.07 |
| CHEMBL394392 | — | IC50 | - | — | - | |
| CHEMBL235784 | — | IC50 | - | — | - | |
| CHEMBL445409 | — | IC50 | - | — | - | |
| CHEMBL266491 | — | IC50 | - | — | - | |
| CHEMBL238338 | — | IC50 | - | — | - | |
| CHEMBL238340 | — | IC50 | - | — | - | |
| CHEMBL235601 | — | IC50 | - | — | - | |
| CHEMBL238365 | — | IC50 | - | — | - | |
| CHEMBL391549 | — | IC50 | - | — | - | |
| CHEMBL396656 | — | IC50 | > | 1.0 | nM | - |
| CHEMBL235379 | — | IC50 | > | 1000.0 | nM | - |