Assay Detail
Binding
CHEMBL899497
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Binding affinity at human PR
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.28 | 5.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL238366 | — | — | 1 | 5.49 |
| CHEMBL391548 | — | — | 1 | 5.35 |
| CHEMBL235159 | — | — | 1 | 5.26 |
| CHEMBL443579 | — | — | 1 | 5.02 |
| CHEMBL238365 | — | — | 1 | - |
| CHEMBL394392 | — | — | 1 | - |
| CHEMBL427678 | — | — | 1 | - |
| CHEMBL396656 | — | — | 1 | - |
| CHEMBL392827 | — | — | 1 | - |
| CHEMBL235601 | — | — | 1 | - |
| CHEMBL235379 | — | — | 1 | - |
| CHEMBL391549 | — | — | 1 | - |
| CHEMBL235378 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL238366 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL391548 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL235159 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL443579 | — | IC50 | = | 9460.0 | nM | 5.02 |
| CHEMBL238365 | — | IC50 | - | — | - | |
| CHEMBL394392 | — | IC50 | - | — | - | |
| CHEMBL427678 | — | IC50 | - | — | - | |
| CHEMBL396656 | — | IC50 | - | — | - | |
| CHEMBL392827 | — | IC50 | - | — | - | |
| CHEMBL235601 | — | IC50 | - | — | - | |
| CHEMBL235379 | — | IC50 | - | — | - | |
| CHEMBL391549 | — | IC50 | - | — | - | |
| CHEMBL235378 | — | IC50 | > | 10000.0 | nM | - |