Assay Detail
ADMET
CHEMBL899757
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Inhibition of microsomal CYP3A4
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.34 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391914 | — | — | 1 | 6.92 |
| CHEMBL236731 | — | — | 1 | 6.77 |
| CHEMBL236732 | — | — | 1 | 6.66 |
| CHEMBL237147 | — | — | 1 | 6.32 |
| CHEMBL237365 | — | — | 1 | 6.19 |
| CHEMBL391915 | — | — | 1 | 6.19 |
| CHEMBL393789 | — | — | 1 | 6.14 |
| CHEMBL397582 | — | — | 1 | 5.89 |
| CHEMBL236939 | — | — | 1 | 5.72 |
| CHEMBL235640 | — | — | 1 | 5.64 |
| CHEMBL237146 | — | — | 1 | 5.57 |
| CHEMBL391028 | — | — | 1 | 5.54 |
| CHEMBL262321 | — | — | 1 | 5.54 |
| CHEMBL397583 | — | — | 1 | 5.47 |
| CHEMBL237578 | — | — | 1 | 5.47 |
| CHEMBL412023 | — | — | 1 | 5.44 |
| CHEMBL235421 | — | — | 1 | 5.44 |
| CHEMBL393204 | — | — | 1 | 5.32 |
| CHEMBL393576 | — | — | 1 | 5.31 |
| CHEMBL396434 | — | — | 1 | 5.28 |
| CHEMBL397581 | — | — | 1 | 5.27 |
| CHEMBL236521 | — | — | 1 | 5.22 |
| CHEMBL236519 | — | — | 1 | 5.20 |
| CHEMBL236520 | — | — | 1 | 5.19 |
| CHEMBL441136 | — | — | 1 | 5.19 |
| CHEMBL397580 | — | — | 1 | 5.17 |
| CHEMBL397584 | — | — | 1 | 5.16 |
| CHEMBL397367 | — | — | 1 | 5.07 |
| CHEMBL237364 | — | — | 1 | 5.05 |
| CHEMBL237577 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391914 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL236731 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL236732 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL237147 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL237365 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL391915 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL393789 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL397582 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL236939 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL235640 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL237146 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL262321 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL391028 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL397583 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL237578 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL412023 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL235421 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL393204 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL393576 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL396434 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL397581 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL236521 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL236519 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL236520 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL441136 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL397580 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL397584 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL397367 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL237364 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL237577 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL412024 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL438683 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL396186 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL393788 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL235955 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL262320 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL397368 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL396431 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL396884 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL396432 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL236940 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL396433 | — | IC50 | > | 50000.0 | nM | - |