Assay Detail
ADMET
CHEMBL900201
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Inhibition of CYP2C9 in human liver microsomes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.20 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235952 | — | — | 1 | 5.80 |
| CHEMBL236162 | — | — | 1 | 5.55 |
| CHEMBL237247 | — | — | 1 | 5.38 |
| CHEMBL237037 | — | — | 1 | 5.24 |
| CHEMBL236163 | — | — | 1 | 4.82 |
| CHEMBL237248 | — | — | 1 | 4.38 |
| CHEMBL235256 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235952 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL236162 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL237247 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL237037 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL236163 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL237248 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL235256 | — | IC50 | < | 400.0 | nM | - |