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Assay Detail

CHEMBL900218

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of human CYP2A6
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Cytochrome P450 2A6 (CHEMBL5282)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist.
Cole DC, Stock JR, Lennox WJ, Bernotas RC, Ellingboe JW, Boikess S, Coupet J, Smith DL, Leung L, Zhang GM, Feng X, Kelly MF, Galante R, Huang P, Dawson LA, Marquis K, Rosenzweig-Lipson S, Beyer CE, Schechter LE.
J Med Chem (2007) 50 : 5535 -5538
PubMed 17948978 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.39 4.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL392760 1 4.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL392760 IC50 = 41000.0 nM 4.39