Assay Detail
Binding
CHEMBL900437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]paroxetine from SERT receptor in human platelet membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.53 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 10.05 |
| CHEMBL240127 | — | — | 1 | 5.00 |
| CHEMBL239271 | — | — | 1 | - |
| CHEMBL240128 | — | — | 1 | - |
| CHEMBL239906 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490 | PAROXETINE | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL240127 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL239271 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL240128 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL239906 | — | Ki | > | 50000.0 | nM | - |