Assay Detail
Functional
CHEMBL900672
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of thrombus formation in rabbit arteriovenous shunt thrombosis model
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.65 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235265 | — | — | 1 | 6.92 |
| CHEMBL378093 | — | — | 1 | 6.85 |
| CHEMBL391484 | — | — | 1 | 6.76 |
| CHEMBL237419 | — | — | 1 | 6.75 |
| CHEMBL231779 | APIXABAN | 4.0 | 1 | 6.48 |
| CHEMBL206335 | RAZAXABAN | 2.0 | 1 | 6.47 |
| CHEMBL237226 | — | — | 1 | 6.35 |
| CHEMBL279187 | — | — | 1 | - |
| CHEMBL237420 | — | — | 1 | - |
| CHEMBL443578 | — | — | 1 | - |
| CHEMBL237228 | — | — | 1 | - |
| CHEMBL235710 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235265 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL378093 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL391484 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL237419 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL231779 | APIXABAN | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL206335 | RAZAXABAN | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL237226 | — | IC50 | = | 445.0 | nM | 6.35 |
| CHEMBL279187 | — | IC50 | - | — | - | |
| CHEMBL237420 | — | IC50 | - | — | - | |
| CHEMBL443578 | — | IC50 | - | — | - | |
| CHEMBL237228 | — | IC50 | - | — | - | |
| CHEMBL235710 | — | IC50 | - | — | - |