Assay Detail
Functional
CHEMBL901268
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reduction of plasma free fatty acid levels in po dosed mouse after 15 mins
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| ED50 | 2 | - | - |
| IC50 | 1 | 5.16 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391813 | — | — | 2 | 5.16 |
| CHEMBL573 | NIACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391813 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL573 | NIACIN | ED50 | = | 8.0 | mg.kg-1 | - |
| CHEMBL391813 | — | ED50 | = | 9.0 | mg.kg-1 | - |