Assay Detail
Binding
CHEMBL901478
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Displacement of [3H]paroxetine from SERT in brain membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.72 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393236 | — | — | 1 | 7.39 |
| CHEMBL245639 | — | — | 1 | 6.85 |
| CHEMBL247284 | — | — | 1 | 6.60 |
| CHEMBL245637 | — | — | 1 | 6.46 |
| CHEMBL429658 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393236 | — | Ki | = | 40.4 | nM | 7.39 |
| CHEMBL245639 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL247284 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL245637 | — | Ki | = | 351.0 | nM | 6.46 |
| CHEMBL429658 | — | Ki | = | 486.0 | nM | 6.31 |