Assay Detail
Binding
CHEMBL901580
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human IMPDH type 1
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Inosine-5'-monophosphate dehydrogenase 1 (CHEMBL1822) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.52 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392203 | — | — | 1 | 9.00 |
| CHEMBL409560 | — | — | 1 | 8.15 |
| CHEMBL235533 | — | — | 1 | 8.00 |
| CHEMBL392204 | — | — | 1 | 7.80 |
| CHEMBL394277 | — | — | 1 | 7.72 |
| CHEMBL264107 | — | — | 1 | 7.70 |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 7.48 |
| CHEMBL265870 | — | — | 1 | 7.35 |
| CHEMBL441190 | — | — | 1 | 7.35 |
| CHEMBL410745 | — | — | 1 | 7.18 |
| CHEMBL414564 | — | — | 1 | 7.14 |
| CHEMBL429702 | — | — | 1 | 7.02 |
| CHEMBL394276 | TIAZOFURIN ADENINE DINUCLEOTIDE | — | 1 | 6.96 |
| CHEMBL410744 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392203 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL409560 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL235533 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL392204 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL394277 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL264107 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL866 | MYCOPHENOLIC ACID | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL265870 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL441190 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL410745 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL414564 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL429702 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL394276 | TIAZOFURIN ADENINE DINUCLEOTIDE | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL410744 | — | Ki | = | 330.0 | nM | 6.48 |