Assay Detail
Binding
CHEMBL901887
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Displacement of [3H]ZM-241385 from adenosine A2A receptor expressed in PC12 cell membrane
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships of adenosines with heterocyclic N6-substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.36 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464859 | NECA | — | 1 | 6.96 |
| CHEMBL240065 | — | — | 1 | 5.26 |
| CHEMBL391031 | — | — | 1 | 5.11 |
| CHEMBL391029 | — | — | 1 | 5.01 |
| CHEMBL240279 | — | — | 1 | 4.46 |
| CHEMBL392149 | TECADENOSON | 2.0 | 1 | - |
| CHEMBL430374 | — | — | 1 | - |
| CHEMBL392720 | — | — | 1 | - |
| CHEMBL240487 | — | — | 1 | - |
| CHEMBL240278 | — | — | 1 | - |
| CHEMBL391030 | — | — | 1 | - |
| CHEMBL240277 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464859 | NECA | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL240065 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL391031 | — | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL391029 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL240279 | — | Ki | = | 34700.0 | nM | 4.46 |
| CHEMBL392149 | TECADENOSON | Ki | > | 100000.0 | nM | - |
| CHEMBL430374 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL392720 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL240487 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL240278 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL391030 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL240277 | — | Ki | > | 100000.0 | nM | - |