Assay Detail
Functional
CHEMBL901936
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Antiproliferative activity against mouse adriamycin-resistant P388 cells after 48 hrs by XTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.64 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 7.30 |
| CHEMBL238102 | — | — | 1 | 6.75 |
| CHEMBL392633 | — | — | 1 | 6.57 |
| CHEMBL238071 | VINDESINE | 3.0 | 1 | 5.94 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL238102 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL392633 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL238071 | VINDESINE | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL428647 | PACLITAXEL | IC50 | > | 5000.0 | nM | - |