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Assay Detail

CHEMBL902038

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ADMET
Reduction of viability of mouse J744 cells after 48 hrs
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type J744
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.
Marma MS, Xia Z, Stewart C, Coxon F, Dunford JE, Baron R, Kashemirov BA, Ebetino FH, Triffitt JT, Russell RG, McKenna CE.
J Med Chem (2007) 50 : 5967 -5975
PubMed 17975902 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.34 5.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL240771 1 5.75
CHEMBL397829 1 5.64
CHEMBL240776 1 5.58
CHEMBL240772 1 5.30
CHEMBL240775 1 5.26
CHEMBL923 RISEDRONIC ACID 4.0 1 4.51
CHEMBL98110 1 -
CHEMBL394759 1 -
CHEMBL394758 1 -
CHEMBL437758 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL240771 IC50 = 1800.0 nM 5.75
CHEMBL397829 IC50 = 2300.0 nM 5.64
CHEMBL240776 IC50 = 2600.0 nM 5.58
CHEMBL240772 IC50 = 5000.0 nM 5.30
CHEMBL240775 IC50 = 5500.0 nM 5.26
CHEMBL923 RISEDRONIC ACID IC50 = 31000.0 nM 4.51
CHEMBL98110 IC50 = 212000.0 nM -
CHEMBL394759 IC50 = 673000.0 nM -
CHEMBL394758 IC50 = 679000.0 nM -
CHEMBL437758 IC50 = 140000.0 nM -