Assay Detail
ADMET
CHEMBL902306
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Inhibition of CYP2C9
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of potent and selective PKC-theta inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.42 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL246970 | — | — | 1 | 6.00 |
| CHEMBL392642 | — | — | 1 | 5.85 |
| CHEMBL246160 | — | — | 1 | 5.08 |
| CHEMBL246161 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL246970 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL392642 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL246160 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL246161 | — | IC50 | = | 17600.0 | nM | 4.75 |