Assay Detail
Binding
CHEMBL902629
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Binding affinity to human glucocorticoid receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
(S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mineralocorticoid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.90 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235206 | — | — | 1 | 8.05 |
| CHEMBL1393 | SPIRONOLACTONE | 4.0 | 1 | 7.49 |
| CHEMBL235209 | — | — | 1 | 6.78 |
| CHEMBL391439 | — | — | 1 | 6.41 |
| CHEMBL237122 | EPIERENONE | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235206 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL1393 | SPIRONOLACTONE | Ki | = | 32.6 | nM | 7.49 |
| CHEMBL235209 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL391439 | — | Ki | = | 387.0 | nM | 6.41 |
| CHEMBL237122 | EPIERENONE | Ki | = | 1758.0 | nM | 5.75 |