Assay Detail
Binding
CHEMBL902630
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Binding affinity to human androgen receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
(S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mineralocorticoid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.18 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1393 | SPIRONOLACTONE | 4.0 | 1 | 7.41 |
| CHEMBL391439 | — | — | 1 | 6.23 |
| CHEMBL235206 | — | — | 1 | 6.16 |
| CHEMBL235209 | — | — | 1 | 6.07 |
| CHEMBL237122 | EPIERENONE | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1393 | SPIRONOLACTONE | Ki | = | 39.4 | nM | 7.41 |
| CHEMBL391439 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL235206 | — | Ki | = | 700.1 | nM | 6.16 |
| CHEMBL235209 | — | Ki | = | 849.0 | nM | 6.07 |
| CHEMBL237122 | EPIERENONE | Ki | = | 8892.0 | nM | 5.05 |