Assay Detail
Binding
CHEMBL902753
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Inhibition of factor 10a
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.54 | 5.22 |
| Ki | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL238707 | — | — | 1 | 5.22 |
| CHEMBL238913 | — | — | 1 | 4.86 |
| CHEMBL391916 | — | — | 1 | 4.70 |
| CHEMBL391344 | — | — | 1 | 4.57 |
| CHEMBL393979 | — | — | 1 | 4.52 |
| CHEMBL214814 | — | — | 1 | 4.47 |
| CHEMBL391968 | — | — | 1 | 4.00 |
| CHEMBL239535 | — | — | 1 | 4.00 |
| CHEMBL391969 | — | — | 1 | - |
| CHEMBL238493 | — | — | 1 | - |
| CHEMBL393592 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL238707 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL238913 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL391916 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL391344 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL393979 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL214814 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL391968 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL239535 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL391969 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL238493 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL393592 | — | IC50 | > | 250000.0 | nM | - |