Assay Detail
ADMET
CHEMBL903475
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Inhibition of human CYP2D6
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.52 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL246920 | — | — | 1 | 7.52 |
| CHEMBL391806 | — | — | 1 | 7.00 |
| CHEMBL245687 | — | — | 1 | 7.00 |
| CHEMBL440230 | — | — | 1 | 6.30 |
| CHEMBL245880 | — | — | 1 | 5.32 |
| CHEMBL391143 | — | — | 1 | 5.26 |
| CHEMBL247733 | — | — | 1 | 5.23 |
| CHEMBL246519 | — | — | 1 | 5.17 |
| CHEMBL247538 | — | — | 1 | 5.09 |
| CHEMBL395408 | — | — | 1 | 5.03 |
| CHEMBL247340 | — | — | 1 | 4.80 |
| CHEMBL442272 | — | — | 1 | 4.52 |
| CHEMBL397392 | — | — | 1 | 4.52 |
| CHEMBL245492 | — | — | 1 | 4.52 |
| CHEMBL245482 | — | — | 1 | - |
| CHEMBL392016 | — | — | 1 | - |
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | - |
| CHEMBL247341 | — | — | 1 | - |
| CHEMBL395931 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL246920 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL391806 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL245687 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL440230 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL245880 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL391143 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL247733 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL246519 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL247538 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL395408 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL247340 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL442272 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL397392 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL245492 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL245482 | — | IC50 | - | — | - | |
| CHEMBL392016 | — | IC50 | - | — | - | |
| CHEMBL1175 | DULOXETINE | IC50 | - | — | - | |
| CHEMBL247341 | — | IC50 | - | — | - | |
| CHEMBL395931 | — | IC50 | - | — | - |