Assay Detail
Binding
CHEMBL903616
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Inhibition of Ack1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.82 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437754 | — | — | 1 | 7.70 |
| CHEMBL240432 | — | — | 1 | 7.08 |
| CHEMBL240429 | — | — | 1 | 6.96 |
| CHEMBL393596 | — | — | 1 | 6.92 |
| CHEMBL240430 | — | — | 1 | 6.82 |
| CHEMBL240431 | — | — | 1 | 6.77 |
| CHEMBL427687 | — | — | 1 | 6.75 |
| CHEMBL239590 | — | — | 1 | 6.75 |
| CHEMBL392990 | — | — | 1 | 6.38 |
| CHEMBL239591 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437754 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL240432 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL240429 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL393596 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL240430 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL240431 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL427687 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL239590 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL392990 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL239591 | — | IC50 | = | 930.0 | nM | 6.03 |