Assay Detail
Functional
CHEMBL904568
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Anticancer activity against human HCT15 cells after 48 hrs by SRB assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxicity evaluation of substituted pyridazino[4,5-b]phenazine-5,12-diones and tri/tetra-azabenzofluorene-5,6-diones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.05 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL229726 | — | — | 1 | 8.00 |
| CHEMBL229678 | — | — | 1 | 7.92 |
| CHEMBL388108 | — | — | 1 | 7.75 |
| CHEMBL229725 | — | — | 1 | 7.62 |
| CHEMBL229727 | — | — | 1 | 7.58 |
| CHEMBL375723 | — | — | 1 | 7.52 |
| CHEMBL229723 | — | — | 1 | 7.13 |
| CHEMBL229677 | — | — | 1 | 7.03 |
| CHEMBL229728 | — | — | 1 | 6.94 |
| CHEMBL375920 | — | — | 1 | 6.91 |
| CHEMBL229365 | — | — | 1 | 6.91 |
| CHEMBL229628 | — | — | 1 | 6.91 |
| CHEMBL390312 | — | — | 1 | 6.87 |
| CHEMBL229004 | — | — | 1 | 6.71 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.65 |
| CHEMBL229680 | — | — | 1 | 6.52 |
| CHEMBL229682 | — | — | 1 | 6.01 |
| CHEMBL229627 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL229726 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL229678 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL388108 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL229725 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL229727 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL375723 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL229723 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL229677 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL229728 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL375920 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL229365 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL229628 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL390312 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL229004 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL229680 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL229682 | — | IC50 | = | 978.0 | nM | 6.01 |
| CHEMBL229627 | — | IC50 | = | 1452.0 | nM | 5.84 |