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Compound Detail

CHEMBL229728

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O=C1c2cnncc2C(=O)c2nc3cc4c(cc3nc21)OCO4

Basic Information

ChEMBL ID CHEMBL229728
Phase Preclinical
Structure Type MOL
InChI Key WOPAKMGWAKJGRN-UHFFFAOYSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

306.2
MW (Da)
0.92
ALogP
8
HBA
0
HBD
104.2
PSA (Ų)
0.47
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H6N4O4
MW 306.24
Aromatic Rings 3
Heavy Atoms 23
NP-Likeness -0.01

Activity Summary

IC50 5 meas. best 7.39

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
SK-OV-3
CHEMBL614925
IC50 7.39 7.39 41.0 1
HCT-15
CHEMBL612263
IC50 6.94 6.94 116.0 1
XF498
CHEMBL613533
IC50 6.93 6.93 118.0 1
A549
CHEMBL392
IC50 6.86 6.86 138.0 1
SK-MEL-2
CHEMBL614917
IC50 6.82 6.82 151.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine