Assay Detail
Functional
CHEMBL904735
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human DU145 cells after 3 days by SRB assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel nitrogen mustard-armed combi-molecules for the selective targeting of epidermal growth factor receptor overexperessing solid tumors: discovery of an unusual structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.99 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225928 | — | — | 1 | 5.58 |
| CHEMBL225930 | — | — | 1 | 5.33 |
| CHEMBL427 | MECHLORETHAMINE | 4.0 | 1 | 5.12 |
| CHEMBL388286 | — | — | 1 | 5.10 |
| CHEMBL225929 | — | — | 1 | 4.98 |
| CHEMBL225721 | — | — | 1 | 4.94 |
| CHEMBL343352 | — | — | 1 | 4.47 |
| CHEMBL225720 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225928 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL225930 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL427 | MECHLORETHAMINE | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL388286 | — | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL225929 | — | IC50 | = | 10550.0 | nM | 4.98 |
| CHEMBL225721 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL343352 | — | IC50 | = | 34140.0 | nM | 4.47 |
| CHEMBL225720 | — | IC50 | = | 37230.0 | nM | 4.43 |