Assay Detail
Binding
CHEMBL904777
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Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells
61
Total Activities
60
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Cell Type | BL21-DE3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Enoyl-acyl-carrier protein reductase (CHEMBL4150) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Discovery of a rhodanine class of compounds as inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 5.09 | 7.46 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228097 | — | — | 1 | 7.46 |
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | 7.18 |
| CHEMBL227563 | — | — | 1 | 6.06 |
| CHEMBL228100 | — | — | 1 | 6.06 |
| CHEMBL228098 | — | — | 2 | 6.06 |
| CHEMBL228099 | — | — | 1 | 6.06 |
| CHEMBL376618 | — | — | 1 | 6.06 |
| CHEMBL228039 | — | — | 1 | 6.06 |
| CHEMBL227981 | — | — | 1 | 6.06 |
| CHEMBL227618 | — | — | 1 | 6.01 |
| CHEMBL228040 | — | — | 1 | 5.82 |
| CHEMBL227619 | — | — | 1 | 5.77 |
| CHEMBL390528 | — | — | 1 | 5.22 |
| CHEMBL227620 | — | — | 1 | 5.21 |
| CHEMBL425480 | — | — | 1 | 5.19 |
| CHEMBL227647 | — | — | 1 | 5.16 |
| CHEMBL376617 | — | — | 1 | 5.00 |
| CHEMBL227675 | — | — | 1 | 4.70 |
| CHEMBL228041 | — | — | 1 | 4.60 |
| CHEMBL374386 | — | — | 1 | 4.54 |
| CHEMBL226812 | — | — | 1 | 4.52 |
| CHEMBL226813 | — | — | 1 | 4.46 |
| CHEMBL611733 | — | — | 1 | 4.40 |
| CHEMBL227592 | — | — | 1 | 4.35 |
| CHEMBL612000 | — | — | 1 | 4.30 |
| CHEMBL226156 | — | — | 1 | 4.30 |
| CHEMBL227191 | — | — | 1 | 4.30 |
| CHEMBL227243 | — | — | 1 | 4.28 |
| CHEMBL226187 | — | — | 1 | 4.26 |
| CHEMBL227300 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228097 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL849 | TRICLOSAN | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL228100 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL228098 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL228099 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL376618 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL228039 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL227981 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL227563 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL227618 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL228040 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL227619 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL390528 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL227620 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL425480 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL227647 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL376617 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL227675 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL228041 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL374386 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL226812 | — | IC50 | = | 30250.0 | nM | 4.52 |
| CHEMBL226813 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL611733 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL227592 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL226156 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL612000 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL227191 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL227243 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL226187 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL227300 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL227299 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL438657 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL226052 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL226157 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL222215 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL227930 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL390087 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL227929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL390086 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL228154 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL388951 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL388950 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL374387 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL227820 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL227138 | — | Activity | - | — | - | |
| CHEMBL390843 | — | Activity | - | — | - | |
| CHEMBL228098 | — | Activity | - | — | - | |
| CHEMBL227140 | — | Activity | - | — | - | |
| CHEMBL390064 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL227593 | — | IC50 | > | 100000.0 | nM | - |