Assay Detail
Functional
CHEMBL904924
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Growth inhibition of retinoid-resistant DU145 cells after 72 hrs
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.18 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176252 | — | — | 1 | 6.30 |
| CHEMBL375062 | — | — | 1 | 5.46 |
| CHEMBL376571 | — | — | 1 | 5.43 |
| CHEMBL226021 | — | — | 1 | 5.16 |
| CHEMBL226068 | — | — | 1 | 5.11 |
| CHEMBL449401 | — | — | 1 | 4.85 |
| CHEMBL227623 | — | — | 1 | 4.82 |
| CHEMBL227622 | — | — | 1 | 4.28 |
| CHEMBL390158 | — | — | 1 | - |
| CHEMBL227678 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176252 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL375062 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL376571 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL226021 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL226068 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL449401 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL227623 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL227622 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL390158 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL227678 | — | IC50 | > | 10000.0 | nM | - |