Assay Detail
Binding
CHEMBL905112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat potassium channel Kv4.2 by patch-clamp method
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
A-type voltage-gated potassium channel KCND2 (CHEMBL1075227) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological studies of novel 2-aminoalkylethers as potential antiarrhythmic agents for the conversion of atrial fibrillation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.06 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 5.66 |
| CHEMBL375475 | — | — | 1 | 5.05 |
| CHEMBL229125 | — | — | 2 | 5.05 |
| CHEMBL652 | FLECAINIDE | 4.0 | 1 | 5.00 |
| CHEMBL387935 | — | — | 1 | 4.96 |
| CHEMBL387671 | — | — | 1 | 4.77 |
| CHEMBL79 | LIDOCAINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1294 | QUINIDINE | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL375475 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL229125 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL652 | FLECAINIDE | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL229125 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL387935 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL387671 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL79 | LIDOCAINE | IC50 | = | 1210000.0 | nM | - |