Assay Detail
Functional
CHEMBL905513
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Antiproliferative activity against HL60 after 24 hrs
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.77 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75978 | 5-DEMETHYLNOBILETIN | — | 1 | 5.68 |
| CHEMBL422237 | — | — | 1 | 5.38 |
| CHEMBL225700 | ARTEMETIN | — | 1 | 5.19 |
| CHEMBL77993 | 3,5,6,7,8,3',4'-HEPTAMETHOXYFLAVONE | — | 1 | 4.88 |
| CHEMBL225698 | HEXAMETHOXYFLAVONE | — | 1 | 4.69 |
| CHEMBL76447 | NOBILETIN | — | 1 | 4.38 |
| CHEMBL225703 | — | — | 1 | 4.32 |
| CHEMBL225704 | — | — | 1 | 4.28 |
| CHEMBL438292 | — | — | 1 | 4.15 |
| CHEMBL77705 | GARDENIN | — | 1 | - |
| CHEMBL225702 | NATSUDAIDAI | — | 1 | - |
| CHEMBL226512 | GARDENIN B | — | 1 | - |
| CHEMBL73930 | TANGERETIN | — | 1 | - |
| CHEMBL226508 | — | — | 1 | - |
| CHEMBL226507 | SINENSETIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75978 | 5-DEMETHYLNOBILETIN | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL422237 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL225700 | ARTEMETIN | IC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL77993 | 3,5,6,7,8,3',4'-HEPTAMETHOXYFLAVONE | IC50 | = | 13310.0 | nM | 4.88 |
| CHEMBL225698 | HEXAMETHOXYFLAVONE | IC50 | = | 20590.0 | nM | 4.69 |
| CHEMBL76447 | NOBILETIN | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL225703 | — | IC50 | = | 47410.0 | nM | 4.32 |
| CHEMBL225704 | — | IC50 | = | 52720.0 | nM | 4.28 |
| CHEMBL438292 | — | IC50 | = | 71180.0 | nM | 4.15 |
| CHEMBL77705 | GARDENIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL225702 | NATSUDAIDAI | IC50 | > | 100000.0 | nM | - |
| CHEMBL226512 | GARDENIN B | IC50 | > | 100000.0 | nM | - |
| CHEMBL73930 | TANGERETIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL226508 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL226507 | SINENSETIN | IC50 | > | 100000.0 | nM | - |