Compound Detail
CHEMBL225698
HEXAMETHOXYFLAVONE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL225698 |
| Name | HEXAMETHOXYFLAVONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CHXSDKWBSFDZEU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names
Molecular Properties
402.4
MW (Da)
3.51
ALogP
8
HBA
0
HBD
85.6
PSA (Ų)
0.59
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.69
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HL-60 CHEMBL383 | IC50 | 4.69 | 4.69 | 20590.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HL-60 | IC50 | = | 20590.0 | nM | 4.69 | Antiproliferative activity against HL60 after 24 hrs | 17391969 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17391969 | 10.1016/j.bmc.2007.03.021 | HL-60 | 2 |
| 17391969 | 10.1016/j.bmc.2007.03.021 | NON-PROTEIN TARGET | 1 |
| 12828478 | 10.1021/np0300784 | Col2 | 1 |
| 12828478 | 10.1021/np0300784 | ADMET | 1 |
| 12828478 | 10.1021/np0300784 | HUVEC | 1 |
| 12828478 | 10.1021/np0300784 | KB | 1 |
| 12828478 | 10.1021/np0300784 | LNCaP | 1 |
| 12828478 | 10.1021/np0300784 | Lu1 | 1 |
| 19193025 | 10.1021/np800721f | Mycobacterium tuberculosis | 1 |
| 22500738 | 10.1021/jf3012163 | Aspergillus niger | 1 |
Data from ChEMBL 36 via Core Engine