Assay Detail
Binding
CHEMBL905766
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Inhibition of PTP1B
25
Total Activities
24
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.29 | 4.72 |
| Ki | 1 | 5.19 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228563 | — | — | 2 | 5.19 |
| CHEMBL228616 | — | — | 1 | 4.57 |
| CHEMBL229471 | — | — | 1 | 4.24 |
| CHEMBL390508 | — | — | 1 | 4.19 |
| CHEMBL228564 | — | — | 1 | 4.17 |
| CHEMBL390509 | — | — | 1 | 4.08 |
| CHEMBL229519 | — | — | 1 | 4.04 |
| CHEMBL229299 | CARBOXYNAPHTHOL | — | 1 | - |
| CHEMBL121772 | — | — | 1 | - |
| CHEMBL323654 | — | — | 1 | - |
| CHEMBL228562 | — | — | 1 | - |
| CHEMBL229301 | — | — | 1 | - |
| CHEMBL229300 | — | — | 1 | - |
| CHEMBL229241 | SULFOSALICYLIC | -1.0 | 1 | - |
| CHEMBL229240 | — | — | 1 | - |
| CHEMBL229239 | — | — | 1 | - |
| CHEMBL229238 | — | — | 1 | - |
| CHEMBL229470 | — | — | 1 | - |
| CHEMBL389855 | — | — | 1 | - |
| CHEMBL229469 | — | — | 1 | - |
| CHEMBL229467 | — | — | 1 | - |
| CHEMBL229466 | — | — | 1 | - |
| CHEMBL387536 | — | — | 1 | - |
| CHEMBL389725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228563 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL228563 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL228616 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL229471 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL390508 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL228564 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL390509 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL229519 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL229299 | CARBOXYNAPHTHOL | IC50 | = | 850000.0 | nM | - |
| CHEMBL121772 | — | IC50 | = | 1279000.0 | nM | - |
| CHEMBL323654 | — | IC50 | = | 149000.0 | nM | - |
| CHEMBL228562 | — | IC50 | = | 215000.0 | nM | - |
| CHEMBL229301 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL229300 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL229241 | SULFOSALICYLIC | IC50 | > | 1000000.0 | nM | - |
| CHEMBL229240 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL389725 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL229238 | — | IC50 | = | 380000.0 | nM | - |
| CHEMBL229470 | — | IC50 | = | 153000.0 | nM | - |
| CHEMBL389855 | — | IC50 | = | 148000.0 | nM | - |
| CHEMBL229469 | — | IC50 | = | 403000.0 | nM | - |
| CHEMBL229467 | — | IC50 | = | 1180000.0 | nM | - |
| CHEMBL229466 | — | IC50 | = | 859000.0 | nM | - |
| CHEMBL387536 | — | IC50 | = | 351000.0 | nM | - |
| CHEMBL229239 | — | IC50 | > | 1000000.0 | nM | - |