Assay Detail
Binding
CHEMBL906674
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Inhibition of GST-tagged bovine p110-alpha expressed in SF9/Baculovirus system by SPA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL2498) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.71 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555968 | — | — | 1 | 9.59 |
| CHEMBL556399 | — | — | 1 | 9.52 |
| CHEMBL536070 | — | — | 1 | 9.11 |
| CHEMBL541643 | — | — | 1 | 8.60 |
| CHEMBL224769 | — | — | 1 | 8.51 |
| CHEMBL538346 | — | — | 1 | 8.44 |
| CHEMBL535170 | — | — | 1 | 8.28 |
| CHEMBL559361 | — | — | 1 | 8.22 |
| CHEMBL541642 | — | — | 1 | 7.85 |
| CHEMBL229046 | — | — | 1 | 7.77 |
| CHEMBL229097 | — | — | 1 | 7.68 |
| CHEMBL229098 | — | — | 1 | 7.09 |
| CHEMBL387636 | — | — | 1 | 6.77 |
| CHEMBL535171 | — | — | 1 | 6.47 |
| CHEMBL389843 | — | — | 1 | 6.40 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 6.20 |
| CHEMBL427066 | — | — | 1 | 6.17 |
| CHEMBL558174 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555968 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL556399 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL536070 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL541643 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL224769 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL538346 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL535170 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL559361 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL541642 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL229046 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL229097 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL229098 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL387636 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL535171 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL389843 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL98350 | LY-294002 | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL427066 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL558174 | — | IC50 | = | 780.0 | nM | 6.11 |