Compound Detail
CHEMBL535171
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CCOC(=O)c1ccc2ncc(/C=N/N(C)S(=O)(=O)c3cc([N+](=O)[O-])ccc3C)n2c1.Cl
Basic Information
| ChEMBL ID | CHEMBL535171 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OGCAJZYPDVQCGJ-YUZSSDIYSA-N |
| Parent Compound | CHEMBL1188106 |
| Active Moiety | CHEMBL1188106 |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
445.5
MW (Da)
2.38
ALogP
9
HBA
0
HBD
136.5
PSA (Ų)
0.24
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL2498 | IC50 | 6.47 | 6.47 | 340.0 | 1 |
| A-375 CHEMBL613859 | IC50 | 5.03 | 5.03 | 9350.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 340.0 | nM | 6.47 | Inhibition of GST-tagged bovine p110-alpha expressed in SF9/Baculovirus system b... | 17601739 |
| A-375 | IC50 | = | 9350.0 | nM | 5.03 | Inhibition of serum-induced proliferation of human A375 cells | 17601739 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17601739 | 10.1016/j.bmc.2007.05.070 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 17601739 | 10.1016/j.bmc.2007.05.070 | A-375 | 1 |
Data from ChEMBL 36 via Core Engine