Assay Detail
Functional
CHEMBL906678
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Inhibition of serum-induced proliferation of human A375 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.95 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555968 | — | — | 1 | 7.48 |
| CHEMBL536070 | — | — | 1 | 7.25 |
| CHEMBL556399 | — | — | 1 | 7.24 |
| CHEMBL541642 | — | — | 1 | 7.05 |
| CHEMBL559361 | — | — | 1 | 6.92 |
| CHEMBL535170 | — | — | 1 | 6.75 |
| CHEMBL224769 | — | — | 1 | 6.14 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.08 |
| CHEMBL229097 | — | — | 1 | 5.05 |
| CHEMBL558174 | — | — | 1 | 5.05 |
| CHEMBL535171 | — | — | 1 | 5.03 |
| CHEMBL229046 | — | — | 1 | 4.92 |
| CHEMBL229098 | — | — | 1 | 4.70 |
| CHEMBL427066 | — | — | 1 | 4.64 |
| CHEMBL387636 | — | — | 1 | - |
| CHEMBL389843 | — | — | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555968 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL536070 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL556399 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL541642 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL559361 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL535170 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL224769 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL98350 | LY-294002 | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL229097 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL558174 | — | IC50 | = | 8960.0 | nM | 5.05 |
| CHEMBL535171 | — | IC50 | = | 9350.0 | nM | 5.03 |
| CHEMBL229046 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL229098 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL427066 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL387636 | — | IC50 | - | — | - | |
| CHEMBL389843 | — | IC50 | - | — | - | |
| CHEMBL53463 | DOXORUBICIN | IC50 | - | — | - | |
| CHEMBL428647 | PACLITAXEL | IC50 | - | — | - |