Assay Detail
Functional
CHEMBL906905
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at NR2E3 by luciferase NCOR release assay in CHO cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Photoreceptor-specific nuclear receptor (CHEMBL4374) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 5.96 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386138 | — | — | 1 | 7.46 |
| CHEMBL213426 | — | — | 1 | 6.83 |
| CHEMBL384623 | — | — | 1 | 6.77 |
| CHEMBL212336 | — | — | 1 | 6.58 |
| CHEMBL213665 | — | — | 1 | 6.48 |
| CHEMBL214562 | — | — | 1 | 6.43 |
| CHEMBL215539 | — | — | 1 | 6.21 |
| CHEMBL214445 | — | — | 1 | 6.01 |
| CHEMBL424715 | — | — | 1 | 5.88 |
| CHEMBL384232 | — | — | 1 | 5.66 |
| CHEMBL214374 | — | — | 1 | 5.58 |
| CHEMBL385936 | — | — | 1 | 5.54 |
| CHEMBL214457 | — | — | 1 | 5.52 |
| CHEMBL386087 | — | — | 1 | 5.39 |
| CHEMBL384066 | — | — | 1 | 5.39 |
| CHEMBL386447 | — | — | 1 | 5.38 |
| CHEMBL215363 | — | — | 1 | 5.14 |
| CHEMBL215498 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386138 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL213426 | — | EC50 | = | 147.0 | nM | 6.83 |
| CHEMBL384623 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL212336 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL213665 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL214562 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL215539 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL214445 | — | EC50 | = | 986.0 | nM | 6.01 |
| CHEMBL424715 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL384232 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL214374 | — | EC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL385936 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL214457 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL386087 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL384066 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL386447 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL215363 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL215498 | — | EC50 | = | 10000.0 | nM | 5.00 |