Assay Detail
Binding
CHEMBL907197
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Displacement of [125I]IMSB from beta amyloid protein 40
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.77 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384465 | — | — | 1 | 10.15 |
| CHEMBL300172 | CHRYSAMINE G | — | 1 | 9.80 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 9.68 |
| CHEMBL215110 | — | — | 1 | 8.03 |
| CHEMBL216553 | — | — | 1 | 7.70 |
| CHEMBL106509 | DEHYDROZINGERONE | — | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384465 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL300172 | CHRYSAMINE G | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL140 | CURCUMIN | Ki | = | 0.208 | nM | 9.68 |
| CHEMBL215110 | — | Ki | = | 9.37 | nM | 8.03 |
| CHEMBL216553 | — | Ki | = | 19.97 | nM | 7.70 |
| CHEMBL106509 | DEHYDROZINGERONE | Ki | = | 54.24 | nM | 7.27 |