Assay Detail
Functional
CHEMBL907378
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Activity at OT receptor assessed as oxytocic activity in absence of magnesium
27
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 22 | - | - |
| Kd | 5 | 6.43 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263090 | — | — | 1 | 6.55 |
| CHEMBL221485 | — | — | 1 | 6.48 |
| CHEMBL412742 | — | — | 1 | 6.35 |
| CHEMBL375187 | — | — | 1 | 6.32 |
| CHEMBL373742 | VASOPRESSIN | 4.0 | 1 | - |
| CHEMBL265858 | — | — | 1 | - |
| CHEMBL414074 | — | — | 1 | - |
| CHEMBL435323 | — | — | 1 | - |
| CHEMBL221436 | — | — | 1 | - |
| CHEMBL1429 | DESMOPRESSIN | 4.0 | 2 | - |
| CHEMBL439318 | — | — | 1 | - |
| CHEMBL539417 | — | — | 1 | - |
| CHEMBL376908 | — | — | 1 | - |
| CHEMBL221847 | — | — | 1 | - |
| CHEMBL265859 | — | — | 1 | - |
| CHEMBL385068 | — | — | 1 | - |
| CHEMBL385739 | — | — | 1 | - |
| CHEMBL375324 | — | — | 1 | - |
| CHEMBL219272 | — | — | 1 | - |
| CHEMBL375323 | — | — | 1 | - |
| CHEMBL375096 | — | — | 1 | - |
| CHEMBL373968 | — | — | 1 | - |
| CHEMBL412973 | — | — | 1 | - |
| CHEMBL412972 | — | — | 1 | - |
| CHEMBL375188 | — | — | 1 | - |
| CHEMBL375325 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263090 | — | Kd | = | 281.84 | nM | 6.55 |
| CHEMBL221485 | — | Kd | = | 331.13 | nM | 6.48 |
| CHEMBL412742 | — | Kd | = | 446.68 | nM | 6.35 |
| CHEMBL375187 | — | Kd | = | 478.63 | nM | 6.32 |
| CHEMBL373742 | VASOPRESSIN | Activity | = | 13.9 | U/mg | - |
| CHEMBL265858 | — | Activity | - | — | - | |
| CHEMBL414074 | — | Activity | - | — | - | |
| CHEMBL435323 | — | Activity | = | 8.0 | U/mg | - |
| CHEMBL221436 | — | Activity | = | 26.0 | U/mg | - |
| CHEMBL1429 | DESMOPRESSIN | Activity | = | 1.5 | U/mg | - |
| CHEMBL439318 | — | Activity | = | 0.9 | U/mg | - |
| CHEMBL539417 | — | Activity | = | 25.0 | U/mg | - |
| CHEMBL376908 | — | Activity | = | 15.0 | U/mg | - |
| CHEMBL221847 | — | Activity | = | 12.0 | U/mg | - |
| CHEMBL1429 | DESMOPRESSIN | Activity | = | 63.0 | U/mg | - |
| CHEMBL265859 | — | Activity | = | 0.67 | U/mg | - |
| CHEMBL385739 | — | Activity | = | 0.14 | U/mg | - |
| CHEMBL375325 | — | Activity | = | 0.15 | U/mg | - |
| CHEMBL375324 | — | Activity | = | 0.027 | U/mg | - |
| CHEMBL219272 | — | Activity | = | 2.8 | U/mg | - |
| CHEMBL375323 | — | Activity | = | 3.1 | U/mg | - |
| CHEMBL375096 | — | Activity | = | 6.49 | U/mg | - |
| CHEMBL373968 | — | Activity | = | 0.046 | U/mg | - |
| CHEMBL412973 | — | Activity | = | 0.27 | U/mg | - |
| CHEMBL412972 | — | Activity | = | 0.054 | U/mg | - |
| CHEMBL375188 | — | Kd | >= | 12882.5 | nM | - |
| CHEMBL385068 | — | Activity | = | 0.06 | U/mg | - |