Assay Detail
Binding
CHEMBL907398
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Inhibition of human 11beta-HSD2 assessed as cortisol disappearance by SPA
19
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
11-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL3746) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.62 | 5.44 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220282 | — | — | 1 | 5.44 |
| CHEMBL220102 | — | — | 1 | 5.08 |
| CHEMBL222365 | — | — | 1 | 4.82 |
| CHEMBL376695 | — | — | 1 | 4.68 |
| CHEMBL219712 | — | — | 1 | 4.62 |
| CHEMBL223138 | — | — | 1 | 4.57 |
| CHEMBL222511 | — | — | 1 | 4.47 |
| CHEMBL373792 | — | — | 1 | 4.30 |
| CHEMBL220153 | — | — | 1 | 4.19 |
| CHEMBL223083 | — | — | 1 | 4.00 |
| CHEMBL222618 | — | — | 1 | - |
| CHEMBL374110 | — | — | 1 | - |
| CHEMBL376293 | — | — | 1 | - |
| CHEMBL223804 | — | — | 1 | - |
| CHEMBL222670 | — | — | 1 | - |
| CHEMBL222669 | — | — | 1 | - |
| CHEMBL220883 | — | — | 1 | - |
| CHEMBL221159 | — | — | 1 | - |
| CHEMBL222319 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220282 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL220102 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL222365 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL376695 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL219712 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL223138 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL222511 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL373792 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL220153 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL223083 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL222618 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL374110 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL376293 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL223804 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL222670 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL222669 | — | Activity | - | — | - | |
| CHEMBL220883 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL221159 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL222319 | — | IC50 | > | 10000.0 | nM | - |