Assay Detail
Binding
CHEMBL907458
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Displacement of [3H]OH-DPAT from rat cortex 5HT1A receptor
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.86 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384657 | — | — | 1 | 9.02 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.85 |
| CHEMBL375297 | — | — | 1 | 8.77 |
| CHEMBL220808 | SARIZOTAN | 3.0 | 1 | 8.65 |
| CHEMBL221692 | ADOPRAZINE | 2.0 | 1 | 8.64 |
| CHEMBL221920 | — | — | 1 | 8.44 |
| CHEMBL221131 | — | — | 1 | 8.26 |
| CHEMBL218261 | — | — | 1 | 8.24 |
| CHEMBL218313 | — | — | 1 | 8.21 |
| CHEMBL219486 | — | — | 1 | 8.02 |
| CHEMBL221743 | — | — | 1 | 7.91 |
| CHEMBL413777 | — | — | 1 | 7.78 |
| CHEMBL441546 | — | — | 1 | 7.68 |
| CHEMBL221957 | — | — | 1 | 7.64 |
| CHEMBL218217 | — | — | 1 | 7.58 |
| CHEMBL220809 | — | — | 1 | 7.53 |
| CHEMBL386988 | — | — | 1 | 7.46 |
| CHEMBL221183 | — | — | 1 | 7.37 |
| CHEMBL425810 | — | — | 1 | 7.33 |
| CHEMBL219111 | — | — | 1 | 7.21 |
| CHEMBL218166 | BIFEPRUNOX | 3.0 | 1 | 7.19 |
| CHEMBL376634 | — | — | 1 | 7.17 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384657 | — | Ki | = | 0.955 | nM | 9.02 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 1.413 | nM | 8.85 |
| CHEMBL375297 | — | Ki | = | 1.698 | nM | 8.77 |
| CHEMBL220808 | SARIZOTAN | Ki | = | 2.239 | nM | 8.65 |
| CHEMBL221692 | ADOPRAZINE | Ki | = | 2.291 | nM | 8.64 |
| CHEMBL221920 | — | Ki | = | 3.631 | nM | 8.44 |
| CHEMBL221131 | — | Ki | = | 5.495 | nM | 8.26 |
| CHEMBL218261 | — | Ki | = | 5.754 | nM | 8.24 |
| CHEMBL218313 | — | Ki | = | 6.166 | nM | 8.21 |
| CHEMBL219486 | — | Ki | = | 9.55 | nM | 8.02 |
| CHEMBL221743 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL413777 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL441546 | — | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL221957 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL218217 | — | Ki | = | 26.3 | nM | 7.58 |
| CHEMBL220809 | — | Ki | = | 29.51 | nM | 7.53 |
| CHEMBL386988 | — | Ki | = | 34.67 | nM | 7.46 |
| CHEMBL221183 | — | Ki | = | 42.66 | nM | 7.37 |
| CHEMBL425810 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL219111 | — | Ki | = | 61.66 | nM | 7.21 |
| CHEMBL218166 | BIFEPRUNOX | Ki | = | 64.57 | nM | 7.19 |
| CHEMBL376634 | — | Ki | = | 67.61 | nM | 7.17 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 1698.24 | nM | 5.77 |