Compound Detail
CHEMBL220809
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Basic Information
| ChEMBL ID | CHEMBL220809 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VSFLBLRRRAGBMV-UHFFFAOYSA-N |
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
351.5
MW (Da)
5.21
ALogP
3
HBA
1
HBD
30.5
PSA (Ų)
0.63
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 9.3
EC50 1 meas. best 7.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL339 | Ki | 9.3 | 9.3 | 0.5 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 7.53 | 7.53 | 29.5 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL214 | EC50 | 7.16 | 7.16 | 69.2 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL322 | Ki | 6.19 | 6.19 | 645.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | Ki | = | 0.5012 | nM | 9.3 | Displacement of [3H]YM-09151-2 from rat striatum D2 receptor | 17300168 |
| 5-hydroxytryptamine receptor 1A | Ki | = | 29.51 | nM | 7.53 | Displacement of [3H]OH-DPAT from rat cortex 5HT1A receptor | 17300168 |
| 5-hydroxytryptamine receptor 1A | EC50 | = | 69.18 | nM | 7.16 | Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation o... | 17300168 |
| 5-hydroxytryptamine receptor 2A | Ki | = | 645.65 | nM | 6.19 | Displacement of [3H]ketanserin from rat cortex 5HT2A receptor | 17300168 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17300168 | 10.1021/jm061180b | 5-hydroxytryptamine receptor 1A | 3 |
| 17300168 | 10.1021/jm061180b | 5-hydroxytryptamine receptor 2A | 1 |
| 17300168 | 10.1021/jm061180b | D(2) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine