Assay Detail
Binding
CHEMBL907459
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Displacement of [3H]ketanserin from rat cortex 5HT2A receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.31 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.08 |
| CHEMBL219111 | — | — | 1 | 6.96 |
| CHEMBL221743 | — | — | 1 | 6.72 |
| CHEMBL413777 | — | — | 1 | 6.52 |
| CHEMBL386988 | — | — | 1 | 6.46 |
| CHEMBL376634 | — | — | 1 | 6.43 |
| CHEMBL425810 | — | — | 1 | 6.25 |
| CHEMBL220809 | — | — | 1 | 6.19 |
| CHEMBL221692 | ADOPRAZINE | 2.0 | 1 | 6.14 |
| CHEMBL218217 | — | — | 1 | 6.14 |
| CHEMBL221957 | — | — | 1 | 5.98 |
| CHEMBL220808 | SARIZOTAN | 3.0 | 1 | 5.67 |
| CHEMBL218166 | BIFEPRUNOX | 3.0 | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 83.18 | nM | 7.08 |
| CHEMBL219111 | — | Ki | = | 109.65 | nM | 6.96 |
| CHEMBL221743 | — | Ki | = | 190.55 | nM | 6.72 |
| CHEMBL413777 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL386988 | — | Ki | = | 346.74 | nM | 6.46 |
| CHEMBL376634 | — | Ki | = | 371.54 | nM | 6.43 |
| CHEMBL425810 | — | Ki | = | 562.34 | nM | 6.25 |
| CHEMBL220809 | — | Ki | = | 645.65 | nM | 6.19 |
| CHEMBL221692 | ADOPRAZINE | Ki | = | 724.44 | nM | 6.14 |
| CHEMBL218217 | — | Ki | = | 724.44 | nM | 6.14 |
| CHEMBL221957 | — | Ki | = | 1047.13 | nM | 5.98 |
| CHEMBL220808 | SARIZOTAN | Ki | = | 2137.96 | nM | 5.67 |
| CHEMBL218166 | BIFEPRUNOX | Ki | = | 3311.31 | nM | 5.48 |