Assay Detail
Functional
CHEMBL907525
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Inhibition of LPS-induced TNFalpha production in THP1 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New modifications to the area of pyrazole-naphthyl urea based p38 MAP kinase inhibitors that bind to the adenine/ATP site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.17 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381743 | — | — | 1 | 8.05 |
| CHEMBL392248 | — | — | 1 | 7.96 |
| CHEMBL245584 | — | — | 1 | 7.96 |
| CHEMBL392249 | — | — | 1 | 7.85 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 7.75 |
| CHEMBL392247 | — | — | 1 | 7.58 |
| CHEMBL410761 | — | — | 1 | 7.50 |
| CHEMBL394099 | — | — | 1 | 7.44 |
| CHEMBL246176 | — | — | 1 | 7.34 |
| CHEMBL246377 | — | — | 1 | 7.25 |
| CHEMBL394100 | — | — | 1 | 7.25 |
| CHEMBL246280 | — | — | 1 | 7.16 |
| CHEMBL245583 | — | — | 1 | 6.98 |
| CHEMBL420047 | — | — | 1 | 6.50 |
| CHEMBL396807 | — | — | 1 | 6.41 |
| CHEMBL246582 | — | — | 1 | 6.33 |
| CHEMBL393890 | — | — | 1 | 5.87 |
| CHEMBL245386 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381743 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL392248 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL245584 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL392249 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL392247 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL410761 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL394099 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL246176 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL246377 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL394100 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL246280 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL245583 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL420047 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL396807 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL246582 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL393890 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL245386 | — | IC50 | = | 1430.0 | nM | 5.84 |