Assay Detail
Functional
CHEMBL907672
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MCH-mediated calcium release in IMR-32 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor (CHEMBL2111437) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.71 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214021 | — | — | 1 | 7.54 |
| CHEMBL216554 | — | — | 1 | 7.46 |
| CHEMBL266725 | — | — | 1 | 7.36 |
| CHEMBL386281 | — | — | 1 | 7.34 |
| CHEMBL216104 | — | — | 1 | 7.24 |
| CHEMBL274168 | — | — | 1 | 7.18 |
| CHEMBL216524 | — | — | 1 | 6.97 |
| CHEMBL216180 | — | — | 1 | 6.96 |
| CHEMBL216482 | — | — | 1 | 6.79 |
| CHEMBL217233 | — | — | 1 | 6.63 |
| CHEMBL269352 | — | — | 1 | 6.26 |
| CHEMBL217435 | — | — | 1 | 6.25 |
| CHEMBL384043 | — | — | 1 | 5.86 |
| CHEMBL384844 | — | — | 1 | 5.62 |
| CHEMBL216323 | — | — | 1 | 5.25 |
| CHEMBL216680 | — | — | 1 | - |
| CHEMBL215457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214021 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL216554 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL266725 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL386281 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL216104 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL274168 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL216524 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL216180 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL216482 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL217233 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL269352 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL217435 | — | IC50 | = | 569.0 | nM | 6.25 |
| CHEMBL384043 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL384844 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL216323 | — | IC50 | = | 5590.0 | nM | 5.25 |
| CHEMBL216680 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL215457 | — | IC50 | > | 10000.0 | nM | - |